MRC1

Across TCGA cell cohorts, MRC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 765 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MRC1-associated GO terms across cancer lineages are Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, Cytosolic ciliogenesis, and Death-inducing signaling complex assembly. Each is linked with MRC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MRC1-to-partner and partner-to-MRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway grouped by MRC1-low versus MRC1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRC1→partner) and Y-score (partner→MRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway →	+0.049	+0.024	<.001	.002	3	5
LUNG_NSCLC_LUSC	Cytosolic ciliogenesis →	+0.152	+0.094	.001	.004	2	5
BLOOD_Lymphoma	Death-inducing signaling complex assembly →	+0.108	+0.021	<.001	.001	3	4
LUNG_NSCLC_LUSC	Gene silencing by piRNA-directed DNA methylation →	-0.189	-0.078	.009	.005	3	4
LUNG_NSCLC_LUSC	Transposable element silencing by piRNA-mediated DNA methylation →	-0.189	-0.078	.009	.005	3	4
BONE	Histone mRNA catabolic process →	+0.058	+0.092	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 765 associations by consensus.

Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway by MRC1 expression — BLOOD_Lymphoma

Explore this box plot interactively →