MRAP2

Across TCGA patient cohorts, MRAP2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRAP2-associated genes across cancer lineages are EGFR, Notch1, and Rab25. Each is linked with MRAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRAP2-to-partner and partner-to-MRAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by MRAP2-low versus MRAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRAP2→partner) and Y-score (partner→MRAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.217	-3.169	.003	.019	3	1
UCEC	Notch1 →	+0.155	+2.820	.017	.035	3	1
UCEC	Rab25 →	-0.326	-3.169	.035	.019	3	1
UCEC	Beclin →	+0.120	+2.584	.006	.011	3	1
SKCM	PKC-a_pS657 →	-0.594	-3.169	.004	.019	3	1
UCEC	Annexin-1 →	+0.789	+2.584	.001	.011	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

EGFR by MRAP2 expression — UCEC

Explore this box plot interactively →