MRAP2

Across TCGA cell cohorts, MRAP2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MRAP2-associated genes across cancer lineages are SPRR2G, MT1B, and TAS2R60. Each is linked with MRAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRAP2-to-partner and partner-to-MRAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRR2G grouped by MRAP2-low versus MRAP2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRAP2→partner) and Y-score (partner→MRAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPRR2G →	+0.349	+4.467	<.001	.004	3	1
SKIN	MT1B →	+0.076	+4.415	<.001	.007	3	1
SKIN	TAS2R60 →	+0.069	+4.415	<.001	.007	3	1
SKIN	OR10S1 →	+0.099	+4.415	<.001	.007	3	1
SKIN	OR51A4 →	+0.010	+5.022	<.001	.002	3	1
SKIN	SERPINA2 →	+0.022	+4.684	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SPRR2G by MRAP2 expression — SKIN

Explore this box plot interactively →