MRAP

Across TCGA patient cohorts, MRAP mutation is significantly associated with the RNA expression of many other genes, with 393 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRAP-associated genes across cancer lineages are RNU6-633P, HSFY1, and RNA5SP405. Each is linked with MRAP in more than 1 cancer types. Because this analysis shows association rather than direction, both MRAP-to-partner and partner-to-MRAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-633P grouped by MRAP-low versus MRAP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRAP→partner) and Y-score (partner→MRAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-633P →	+0.501	+4.374	<.001	.002	3	2
BLCA	HSFY1 →	+0.041	+5.411	<.001	.005	3	2
UCEC	RNA5SP405 →	+0.470	+3.997	<.001	.001	3	2
UCEC	RNU5E-9P →	+0.272	+4.148	<.001	.006	3	2
STAD	RN7SKP181 →	+0.375	+3.691	<.001	.008	3	2
STAD	PTP4A1P5 →	+0.145	+4.343	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 393 associations by consensus.

RNU6-633P by MRAP expression — COAD

Explore this box plot interactively →