MRAP

Across TCGA cell cohorts, MRAP RNA expression is significantly associated with the mutation status of many other genes, with 176 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible MRAP-associated genes across cancer lineages are GRIN2B, ARHGEF10, and CFAP206. Each is linked with MRAP in more than 2 cancer types. Because this analysis shows association rather than direction, both MRAP-to-partner and partner-to-MRAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRIN2B grouped by MRAP-low versus MRAP-high in STOMACH.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRAP→partner) and Y-score (partner→MRAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GRIN2B →	+3.209	+0.024	.007	<.001	3	3
BREAST	ARHGEF10 →	+4.672	+0.041	.002	.004	3	2
BREAST	CFAP206 →	+4.672	+0.039	.002	.008	3	2
UPPER_AERODIGESTIVE_TRACT	RICTOR →	+4.736	+0.028	.009	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	CDK12 →	+4.736	+0.032	.009	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	ATP1A2 →	+4.736	+0.028	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 176 associations by consensus.

GRIN2B by MRAP expression — STOMACH

Explore this box plot interactively →