MRAP-AS1

Across TCGA pan-cancer cohorts, MRAP-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated MRAP-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher MRAP-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRAP-AS1 expression acts as an unfavorable survival marker, although some lineages such as READ and UCS show a favorable association.

UVM, READ, and LUAD are the cancer types where MRAP-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.435	0.824	<.001	66	view →
READ	OS	Median	II,III,IV	0.895	0.392	<.001	60	view →
LUAD	DFS	Median	III,IV	0.481	0.799	<.001	42	view →
LGG	OS	Median	All	0.749	0.863	<.001	35	view →
THCA	DFS	Median	II,III,IV	0.615	0.830	.002	35	view →
UCS	OS	Median	III,IV	0.534	0.192	.010	30	view →
PAAD	OS	Quartile	All	0.724	0.333	.001	28	view →
KIRC	DFS	Tertile	IV	0.185	0.560	.001	26	view →
STAD	DFS	Tertile	III,IV	0.419	0.735	<.001	23	view →
BRCA	OS	Median	III,IV	0.642	0.428	.007	21	view →
ESCA	DFS	Tertile	IV	0.231	0.704	.024	18	view →
ACC	DFS	Median	All	0.528	0.786	.007	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

MRAP-AS1–UVM (DFS)

Open the UVM breakdown →