MR1

Across TCGA patient cohorts, MR1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MR1-associated genes across cancer lineages are Notch1, FoxM1, and FOXO3a_pS318_S321. Each is linked with MR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MR1-to-partner and partner-to-MR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MR1-low versus MR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MR1→partner) and Y-score (partner→MR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.165	+2.000	.002	.010	3	2
UCEC	FoxM1 →	+0.251	+2.009	.013	.017	3	1
UCEC	FOXO3a_pS318_S321 →	-0.123	-2.000	.012	.010	3	1
UCEC	ACVRL1 →	-0.122	-2.439	.022	.019	3	1
UCEC	MEK1 →	+0.335	+2.321	.019	.033	3	1
UCEC	p27_pT198 →	+0.092	+2.000	.028	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Notch1 by MR1 expression — UCEC

Explore this box plot interactively →