MR1

Across TCGA cell cohorts, MR1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. CNS shows the largest number of these associations.

The most reproducible MR1-associated genes across cancer lineages are CYP11B1, OR5M8, and SLC22A12. Each is linked with MR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MR1-to-partner and partner-to-MR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP11B1 grouped by MR1-low versus MR1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MR1→partner) and Y-score (partner→MR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CYP11B1 →	+0.022	+4.981	<.001	.008	3	1
CNS	OR5M8 →	+0.022	+5.754	<.001	.002	3	1
CNS	SLC22A12 →	+0.012	+5.754	.003	.002	3	1
CNS	OR8K3 →	+0.013	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CYP11B1 by MR1 expression — CNS

Explore this box plot interactively →