MPZL3

Across TCGA cell cohorts, MPZL3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MPZL3-associated genes across cancer lineages are NGB, OR1L1, and OR56A1. Each is linked with MPZL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPZL3-to-partner and partner-to-MPZL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NGB grouped by MPZL3-low versus MPZL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPZL3→partner) and Y-score (partner→MPZL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NGB →	+0.066	+4.095	<.001	.009	3	1
LARGE_INTESTINE	OR1L1 →	+0.029	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR56A1 →	+0.020	+4.467	<.001	.004	3	1
LARGE_INTESTINE	OR2L5 →	+0.004	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

NGB by MPZL3 expression — LARGE_INTESTINE

Explore this box plot interactively →