MPZL2

Across TCGA patient cohorts, MPZL2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPZL2-associated genes across cancer lineages are ERK2, Fibronectin, and GATA6. Each is linked with MPZL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPZL2-to-partner and partner-to-MPZL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by MPZL2-low versus MPZL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPZL2→partner) and Y-score (partner→MPZL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.217	+2.999	.015	.035	3	1
UCEC	Fibronectin →	-0.384	-2.584	.012	.011	3	1
UCEC	GATA6 →	-0.211	-2.452	.004	.020	3	1
UCEC	NF2 →	+0.274	+2.999	.006	.035	3	1
UCEC	S6_pS240_S244 →	+0.389	+3.013	.040	.018	3	1
UCEC	XRCC1 →	+0.149	+3.000	.041	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ERK2 by MPZL2 expression — UCEC

Explore this box plot interactively →