Across TCGA patient cohorts, MPZL1 mutation is significantly associated with the RNA expression of many other genes, with 150 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPZL1-associated genes across cancer lineages are PPP2R2B-IT1, RNU2-61P, and NUTF2P3. Each is linked with MPZL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPZL1-to-partner and partner-to-MPZL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPZL1→partner) and Y-score (partner→MPZL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PPP2R2B-IT1 →	+0.078	+4.385	<.001	.008	3	2
COAD	RNU2-61P →	+1.823	+5.251	<.001	.003	3	2
COAD	NUTF2P3 →	+0.570	+4.543	<.001	.005	3	2
COAD	RN7SL743P →	+0.361	+4.446	.004	.006	3	2
SKCM	RNA5SP74 →	+0.375	+4.351	<.001	.002	3	2
UCEC	RNU6-440P →	+0.174	+4.242	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 150 associations by consensus.

Exploration

MPZL1 survival (RNA) · tumor vs normal (RNA) · all MPZL1 data types