Across TCGA patient cohorts, MPZL1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPZL1-associated genes across cancer lineages are eIF4G, Gab2, and p38-MAPK_pT180_Y182. Each is linked with MPZL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPZL1-to-partner and partner-to-MPZL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPZL1→partner) and Y-score (partner→MPZL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.354	+3.000	.048	.037	3	1
UCEC	Gab2 →	+0.593	+3.000	.004	.036	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.637	-2.986	.014	.037	3	1
UCEC	p70-S6K_pT389 →	-0.246	-3.000	.025	.037	3	1
UCEC	Rad50 →	-0.326	-3.000	.020	.037	3	1
UCEC	p27 →	-0.282	-3.000	.025	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

MPZL1 survival (RNA) · tumor vs normal (RNA) · all MPZL1 data types