MPV17

Across TCGA patient cohorts, MPV17 mutation is significantly associated with the RNA expression of many other genes, with 1,606 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPV17-associated genes across cancer lineages are RNU6-597P, RNA5SP325, and RN7SKP188. Each is linked with MPV17 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPV17-to-partner and partner-to-MPV17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-597P grouped by MPV17-low versus MPV17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPV17→partner) and Y-score (partner→MPV17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-597P →	+0.508	+2.448	<.001	.003	3	2
COAD	RNA5SP325 →	+0.997	+5.602	.006	.004	3	2
COAD	RN7SKP188 →	+0.458	+7.734	<.001	<.001	3	2
UCEC	PCDHB16 →	+0.985	+3.330	<.001	.005	3	1
UCEC	ZFP91P1 →	+0.163	+3.818	.003	<.001	3	1
UCEC	LINC02340 →	+0.549	+3.775	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,606 associations by consensus.

RNU6-597P by MPV17 expression — UCEC

Explore this box plot interactively →