MPV17

Across TCGA patient cohorts, MPV17 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPV17-associated genes across cancer lineages are ERK2, Caspase-7-cleavedD198, and Chk2_pT68. Each is linked with MPV17 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPV17-to-partner and partner-to-MPV17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by MPV17-low versus MPV17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPV17→partner) and Y-score (partner→MPV17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.228	+3.000	.023	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+0.823	+2.827	.008	.035	3	1
UCEC	Chk2_pT68 →	-0.192	-3.321	.049	.010	3	1
UCEC	Rab25 →	-0.434	-3.321	.012	.010	2	1
UCEC	EGFR_pY1068 →	-0.305	-3.321	.020	.010	1	1
UCEC	A-Raf_pS299 →	-0.177	-3.321	.004	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ERK2 by MPV17 expression — UCEC

Explore this box plot interactively →