MPPED2

Across TCGA patient cohorts, MPPED2 mutation is significantly associated with the RNA expression of many other genes, with 4,158 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPPED2-associated genes across cancer lineages are DSN1, WDR62, and UBE2T. Each is linked with MPPED2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MPPED2-to-partner and partner-to-MPPED2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSN1 grouped by MPPED2-low versus MPPED2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPPED2→partner) and Y-score (partner→MPPED2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DSN1 →	+0.445	+1.709	.001	<.001	3	3
UCEC	WDR62 →	+0.635	+1.917	<.001	<.001	3	3
UCEC	UBE2T →	+0.624	+2.189	<.001	<.001	3	3
UCEC	RAD54L →	+0.647	+4.000	<.001	<.001	3	3
UCEC	MYBL2 →	+0.638	+3.191	.001	<.001	3	3
UCEC	E2F1 →	+0.769	+1.917	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,158 associations by consensus.

DSN1 by MPPED2 expression — UCEC

Explore this box plot interactively →