MPPED2

Across TCGA patient cohorts, MPPED2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPPED2-associated genes across cancer lineages are C-Raf, FoxM1, and JNK2. Each is linked with MPPED2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MPPED2-to-partner and partner-to-MPPED2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by MPPED2-low versus MPPED2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPPED2→partner) and Y-score (partner→MPPED2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.120	+1.263	.006	.019	3	3
UCEC	FoxM1 →	+0.218	+1.700	.005	.001	3	2
UCEC	JNK2 →	+0.155	+1.064	.010	.048	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.352	-1.440	.010	.022	3	2
UCEC	p62 Lck ligand →	+0.305	+2.999	.002	<.001	3	2
UCEC	STAT3_pY705 →	-0.327	-1.864	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

C-Raf by MPPED2 expression — UCEC

Explore this box plot interactively →