MPPED2

Across TCGA cell cohorts, MPPED2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,226 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MPPED2-associated GO terms across cancer lineages are Positive regulation of double-strand break repair via homologous recombination, Regulation of nucleotide-excision repair, and Mitotic cell cycle phase transition. Each is linked with MPPED2 in more than 9 cancer types. Because this analysis shows association rather than direction, both MPPED2-to-partner and partner-to-MPPED2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair via homologous recombination grouped by MPPED2-low versus MPPED2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MPPED2→partner) and Y-score (partner→MPPED2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of double-strand break repair via homologous recombination →	+0.116	+1.827	<.001	.003	3	8
SOFT_TISSUE	Regulation of nucleotide-excision repair →	+0.091	+1.355	.001	.001	1	10
LUNG_SCLC	Mitotic cell cycle phase transition →	+0.082	+2.489	<.001	.001	3	8
SOFT_TISSUE	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.137	+1.770	<.001	<.001	3	7
SOFT_TISSUE	Regulation of double-strand break repair →	+0.072	+1.424	<.001	<.001	3	7
LUNG_SCLC	Cell cycle phase transition →	+0.074	+2.059	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,226 associations by consensus.

Positive regulation of double-strand break repair via homologous recombination by MPPED2 expression — LUNG_SCLC

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