MPPED2

Across TCGA cell cohorts, MPPED2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MPPED2-associated genes across cancer lineages are PNPLA5, CCL25, and SHISAL2B. Each is linked with MPPED2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPPED2-to-partner and partner-to-MPPED2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNPLA5 grouped by MPPED2-low versus MPPED2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPPED2→partner) and Y-score (partner→MPPED2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PNPLA5 →	+0.052	+4.273	<.001	.006	3	1
SKIN	CCL25 →	+0.050	+4.095	.009	.009	3	1
SKIN	SHISAL2B →	+0.302	+4.273	<.001	.006	3	1
SKIN	DIPK2B →	+0.006	+4.467	<.001	.004	3	1
SKIN	FGF3 →	+0.076	+4.684	<.001	.002	3	1
SKIN	HELT →	+0.049	+4.095	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PNPLA5 by MPPED2 expression — SKIN

Explore this box plot interactively →