Across TCGA patient cohorts, MPPED1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPPED1-associated genes across cancer lineages are PDCD4, TIGAR, and Bax. Each is linked with MPPED1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPPED1-to-partner and partner-to-MPPED1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPPED1→partner) and Y-score (partner→MPPED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.605	-2.222	.002	.011	3	2
UCEC	TIGAR →	+0.205	+2.248	.001	.006	3	2
UCEC	Bax →	+0.223	+2.222	.028	.011	3	2
UCEC	Cyclin-B1 →	+0.512	+2.999	.031	.035	3	2
UCEC	eEF2 →	+0.387	+1.700	.010	.044	3	1
UCEC	EGFR_pY1068 →	-0.279	-2.584	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

MPPED1 survival (RNA) · tumor vs normal (RNA) · all MPPED1 data types