Across TCGA cell cohorts, MPPED1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MPPED1-associated genes across cancer lineages are ADAM2, PRAMEF20, and C9orf135. Each is linked with MPPED1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPPED1-to-partner and partner-to-MPPED1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPPED1→partner) and Y-score (partner→MPPED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ADAM2 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	C9orf135 →	+0.108	+3.878	<.001	.003	3	1
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

MPPED1 survival (RNA) · tumor vs normal (RNA) · all MPPED1 data types