MPPE1

Across TCGA patient cohorts, MPPE1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPPE1-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and JNK2. Each is linked with MPPE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPPE1-to-partner and partner-to-MPPE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MPPE1-low versus MPPE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPPE1→partner) and Y-score (partner→MPPE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.267	-2.700	.018	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.181	-1.986	.017	.032	3	1
UCEC	JNK2 →	+0.295	+2.700	<.001	.006	3	1
UCEC	MEK1 →	+0.349	+3.321	.034	.010	3	1
UCEC	Shc_pY317 →	-0.181	-3.169	.008	.019	3	1
UCEC	STAT3_pY705 →	-0.407	-3.311	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by MPPE1 expression — UCEC

Explore this box plot interactively →