MPPE1

Across TCGA cell cohorts, MPPE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,223 significant associations in total. CNS shows the largest number of these associations.

The most reproducible MPPE1-associated GO terms across cancer lineages are Vacuole organization, Lysosomal transport, and Vacuolar transport. Each is linked with MPPE1 in more than 15 cancer types. Because this analysis shows association rather than direction, both MPPE1-to-partner and partner-to-MPPE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vacuole organization grouped by MPPE1-low versus MPPE1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MPPE1→partner) and Y-score (partner→MPPE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Vacuole organization →	+0.063	+1.025	.001	.005	3	16
OESOPHAGUS	Lysosomal transport →	+0.094	+1.519	<.001	<.001	3	15
OESOPHAGUS	Vacuolar transport →	+0.090	+1.490	<.001	<.001	3	14
OVARY	Establishment of protein localization to vacuole →	+0.073	+0.854	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle transport →	+0.066	+1.224	.002	<.001	2	14
LARGE_INTESTINE	Endosomal transport →	+0.040	+0.742	.003	.006	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,223 associations by consensus.

Vacuole organization by MPPE1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →