MPP7

Across TCGA pan-cancer cohorts, MPP7 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MPP7 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MPP7 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MPP7 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and COAD are the cancer types where MPP7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.927	0.495	.004	20	view →
PDAC	DFS	Median	All	0.421	0.216	.015	17	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
LSCC	DFS	Median	II,III,IV	0.879	0.671	.020	6	view →
LUAD	DFS	Quartile	II,III,IV	0.635	1.000	.022	4	view →
UCEC	DFS	Median	All	0.943	0.870	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MPP7–CCRCC (OS)

Open the CCRCC breakdown →