MPP7

Across TCGA patient cohorts, MPP7 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPP7-associated genes across cancer lineages are PCNA, Caspase-8, and MSH2. Each is linked with MPP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPP7-to-partner and partner-to-MPP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MPP7-low versus MPP7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP7→partner) and Y-score (partner→MPP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.166	+1.662	.030	.011	3	2
UCEC	Caspase-8 →	-0.223	-2.584	.011	.001	3	2
SKCM	MSH2 →	+0.180	+2.321	.014	.032	3	2
UCEC	JNK2 →	+0.197	+2.486	.005	.009	3	1
UCEC	p62 Lck ligand →	+0.246	+1.362	.032	.037	3	1
UCEC	Annexin-1 →	+0.420	+2.019	.023	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PCNA by MPP7 expression — UCEC

Explore this box plot interactively →