MPP7

Across TCGA cell cohorts, MPP7 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MPP7-associated genes across cancer lineages are BANF2, SLC17A2, and C4orf50. Each is linked with MPP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPP7-to-partner and partner-to-MPP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BANF2 grouped by MPP7-low versus MPP7-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP7→partner) and Y-score (partner→MPP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BANF2 →	+0.096	+5.643	<.001	.002	3	1
LUNG_NSCLC_LUAD	SLC17A2 →	+0.016	+6.266	<.001	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	C4orf50 →	+0.013	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	TRIM77 →	+0.030	+5.357	<.001	.003	3	1
LARGE_INTESTINE	PAK5 →	+0.144	+4.054	.001	.004	3	1
LARGE_INTESTINE	PTH →	+0.049	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

BANF2 by MPP7 expression — BLOOD_Lymphoma

Explore this box plot interactively →