MPP6

Across TCGA pan-cancer cohorts, MPP6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MPP6 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MPP6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MPP6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, LSCC, and HNSC are the cancer types where MPP6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.921	0.748	.002	19	view →
LSCC	DFS	Tertile	All	0.896	0.614	.004	13	view →
HNSC	OS	Median	All	0.484	1.000	.038	10	view →
PDAC	OS	Quartile	All	0.234	0.601	.005	7	view →
CCRCC	DFS	Median	All	0.674	0.812	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MPP6–LUAD (OS)

Open the LUAD breakdown →