MPP6

Across TCGA patient cohorts, MPP6 mutation is significantly associated with the RNA expression of many other genes, with 3,579 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPP6-associated genes across cancer lineages are GUCA1B, RN7SL479P, and MIR4710. Each is linked with MPP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both MPP6-to-partner and partner-to-MPP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA1B grouped by MPP6-low versus MPP6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP6→partner) and Y-score (partner→MPP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GUCA1B →	+0.702	+1.932	<.001	.003	3	3
LUSC	RN7SL479P →	+0.168	+5.404	.003	.005	3	3
SKCM	MIR4710 →	+0.283	+2.168	<.001	.002	3	3
UCEC	APOBEC3H →	+0.583	+3.742	<.001	<.001	3	2
UCEC	NDUFAF5 →	+0.431	+2.467	<.001	<.001	3	2
UCEC	PCSK1N →	-1.526	-1.978	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,579 associations by consensus.

GUCA1B by MPP6 expression — SKCM

Explore this box plot interactively →