MPP6

Across TCGA patient cohorts, MPP6 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPP6-associated genes across cancer lineages are p27_pT198, PDCD4, and Acetyl-a-Tubulin-Lys40. Each is linked with MPP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPP6-to-partner and partner-to-MPP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by MPP6-low versus MPP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP6→partner) and Y-score (partner→MPP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.118	+3.321	.003	.009	3	2
UCEC	PDCD4 →	-0.473	-2.000	.007	.029	3	2
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.624	+1.874	.009	.049	3	1
SKCM	Chk1 →	+0.185	+3.016	.026	.018	3	1
UCEC	EGFR_pY1068 →	-0.215	-1.765	.022	.014	3	1
UCEC	eIF4E →	+0.163	+2.169	.039	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

p27_pT198 by MPP6 expression — UCEC

Explore this box plot interactively →