MPP6

Across TCGA cell cohorts, MPP6 mutation is significantly associated with the mutation status of many other genes, with 1,733 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MPP6-associated genes across cancer lineages are PDZD2, PARD3, and PLCXD3. Each is linked with MPP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both MPP6-to-partner and partner-to-MPP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDZD2 grouped by MPP6-low versus MPP6-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP6→partner) and Y-score (partner→MPP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PDZD2 →	+3.232	+3.523	.006	.006	1	3
LUNG_NSCLC_LUAD	PARD3 →	+4.187	+5.000	.008	.008	1	3
BLOOD_Lymphoma	PLCXD3 →	+4.969	+4.014	.008	.008	1	3
BLOOD_Lymphoma	MTOR →	+3.384	+4.169	<.001	<.001	1	3
LARGE_INTESTINE	CLCN2 →	+2.321	+2.643	.004	.004	1	3
LARGE_INTESTINE	BICC1 →	+2.321	+2.643	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,733 associations by consensus.

PDZD2 by MPP6 expression — BLOOD_Lymphoma

Explore this box plot interactively →