MPP5

Across TCGA pan-cancer cohorts, MPP5 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MPP5 data layer compared with 19 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher MPP5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MPP5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

KIRP, UCEC, and COAD are the cancer types where MPP5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.122	0.875	<.001	30	view →
UCEC	DFS	Median	All	0.946	0.621	.010	14	view →
COAD	OS	Median	All	0.168	0.806	.002	12	view →
ESCA	OS	Median	All	0.311	0.707	.003	12	view →
BLCA	DFS	Median	All	1.000	0.324	.023	9	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MPP5–KIRP (DFS)

Open the KIRP breakdown →