MPP5

Across TCGA pan-cancer cohorts, MPP5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MPP5 data layer compared with 19 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MPP5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MPP5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

PDAC, GBM, and HNSC are the cancer types where MPP5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.716	0.812	.010	7	view →
GBM	OS	Median	All	0.261	0.531	.013	6	view →
HNSC	DFS	Tertile	III,IV	0.819	0.548	.012	5	view →
LSCC	DFS	Median	All	1.000	0.905	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MPP5–PDAC (DFS)

Open the PDAC breakdown →