MPP5

Across TCGA patient cohorts, MPP5 mutation is significantly associated with the RNA expression of many other genes, with 4,532 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPP5-associated genes across cancer lineages are MIR8053, FAR1P1, and CPVL-AS1. Each is linked with MPP5 in more than 3 cancer types. Because this analysis shows association rather than direction, both MPP5-to-partner and partner-to-MPP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8053 grouped by MPP5-low versus MPP5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP5→partner) and Y-score (partner→MPP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR8053 →	+0.600	+6.328	<.001	.001	3	4
UCEC	FAR1P1 →	+0.050	+1.611	.009	.001	3	3
CESC	CPVL-AS1 →	+0.095	+4.425	<.001	<.001	3	2
HNSC	VN2R1P →	+0.061	+4.141	<.001	.003	3	2
HNSC	RNA5SP478 →	+0.197	+4.424	.002	.008	3	2
CESC	RNA5SP420 →	+0.146	+4.842	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,532 associations by consensus.

MIR8053 by MPP5 expression — SKCM

Explore this box plot interactively →