MPP5

Across TCGA cell cohorts, MPP5 mutation is significantly associated with the RNA expression of many other genes, with 1,375 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MPP5-associated genes across cancer lineages are PRSS58, PES1, and MAPK1. Each is linked with MPP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPP5-to-partner and partner-to-MPP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS58 grouped by MPP5-low versus MPP5-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP5→partner) and Y-score (partner→MPP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
LARGE_INTESTINE	PES1 →	+0.525	+2.675	.002	.003	3	1
LARGE_INTESTINE	MAPK1 →	+0.887	+3.169	<.001	.006	3	1
LARGE_INTESTINE	SRRD →	+0.795	+3.169	<.001	.006	3	1
LARGE_INTESTINE	GCAT →	+1.241	+3.321	.001	.003	3	1
LARGE_INTESTINE	EIF3L →	+0.475	+3.087	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,375 associations by consensus.

PRSS58 by MPP5 expression — PANCREAS

Explore this box plot interactively →