MPP3

Across TCGA patient cohorts, MPP3 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPP3-associated genes across cancer lineages are Cyclin-B1, FoxM1, and JNK_pT183_Y185. Each is linked with MPP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MPP3-to-partner and partner-to-MPP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by MPP3-low versus MPP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP3→partner) and Y-score (partner→MPP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.692	+3.584	.001	.002	3	3
UCEC	FoxM1 →	+0.259	+2.087	.009	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.181	-1.664	.005	.023	3	2
UCEC	mTOR_pS2448 →	-0.145	-3.439	.011	.005	3	2
UCEC	Notch1 →	+0.174	+3.713	.001	<.001	3	2
UCEC	PDCD4 →	-0.640	-2.584	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Cyclin-B1 by MPP3 expression — UCEC

Explore this box plot interactively →