MPP3

Across TCGA cell cohorts, MPP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,647 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MPP3-associated GO terms across cancer lineages are Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, Assembly of actomyosin apparatus involved in cytokinesis, and Actomyosin contractile ring assembly. Each is linked with MPP3 in more than 14 cancer types. Because this analysis shows association rather than direction, both MPP3-to-partner and partner-to-MPP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by MPP3-low versus MPP3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP3→partner) and Y-score (partner→MPP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.174	+1.306	<.001	<.001	3	15
OVARY	Assembly of actomyosin apparatus involved in cytokinesis →	+0.140	+0.723	.005	.008	3	13
OVARY	Actomyosin contractile ring assembly →	+0.140	+0.723	.005	.008	3	13
BONE	Viral translational termination-reinitiation →	+0.092	+1.579	<.001	<.001	3	12
BONE	Chromosome separation →	+0.180	+1.142	<.001	.004	3	12
SKIN	Positive regulation of cell cycle checkpoint →	+0.128	+1.107	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,647 associations by consensus.

Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I by MPP3 expression — BONE

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