MPP3

Across TCGA cell cohorts, MPP3 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MPP3-associated genes across cancer lineages are C1QL2, TAAR6, and GFRAL. Each is linked with MPP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPP3-to-partner and partner-to-MPP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QL2 grouped by MPP3-low versus MPP3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP3→partner) and Y-score (partner→MPP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C1QL2 →	+0.012	+4.922	<.001	.009	3	1
BLOOD_Leukemia	TAAR6 →	+0.018	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GFRAL →	+0.033	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	LRRTM3 →	+0.006	+5.539	<.001	.003	3	1
SKIN	CLEC10A →	+0.022	+3.688	.001	.002	3	1
SKIN	C1QC →	+0.024	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

C1QL2 by MPP3 expression — BLOOD_Leukemia

Explore this box plot interactively →