MPP2

Across TCGA pan-cancer cohorts, MPP2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MPP2 data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MPP2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MPP2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where MPP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.942	0.433	.002	34	view →
CCRCC	DFS	Tertile	II,III,IV	0.125	0.904	.024	12	view →
HNSC	OS	Median	All	1.000	0.224	.036	4	view →
GBM	DFS	Quartile	All	0.813	0.674	.020	2	view →
LSCC	OS	Median	II,III,IV	0.874	1.000	.035	2	view →
PDAC	OS	Tertile	All	1.000	0.764	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MPP2–LUAD (DFS)

Open the LUAD breakdown →