MPP2

Across TCGA patient cohorts, MPP2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPP2-associated genes across cancer lineages are STAT3_pY705, c-Met_pY1235, and Cyclin-B1. Each is linked with MPP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MPP2-to-partner and partner-to-MPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by MPP2-low versus MPP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP2→partner) and Y-score (partner→MPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.364	-1.925	<.001	.004	3	3
UCEC	c-Met_pY1235 →	+0.073	+2.147	.002	<.001	3	3
UCEC	Cyclin-B1 →	+0.522	+2.087	.003	.004	3	3
UCEC	FoxM1 →	+0.181	+1.523	.028	.008	3	2
UCEC	PDCD4 →	-0.356	-1.289	.017	.023	3	2
UCEC	Shc_pY317 →	-0.104	-1.289	.031	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

STAT3_pY705 by MPP2 expression — UCEC

Explore this box plot interactively →