MPP2

Across TCGA cell cohorts, MPP2 mutation is significantly associated with the RNA expression of many other genes, with 132 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MPP2-associated genes across cancer lineages are KRTAP13-2, ARMH2, and LECT2. Each is linked with MPP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPP2-to-partner and partner-to-MPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP13-2 grouped by MPP2-low versus MPP2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP2→partner) and Y-score (partner→MPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KRTAP13-2 →	+0.229	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ARMH2 →	+0.020	+4.643	<.001	.008	3	1
BLOOD_Leukemia	LECT2 →	+0.210	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OC90 →	+0.006	+5.201	.003	.006	3	1
LARGE_INTESTINE	DEPDC5 →	+0.554	+3.459	.002	.001	3	1
LARGE_INTESTINE	SLC25A11 →	+0.517	+2.502	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 132 associations by consensus.

KRTAP13-2 by MPP2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →