MPP1

Across TCGA pan-cancer cohorts, MPP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MPP1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MPP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MPP1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where MPP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.910	0.619	.011	17	view →
LSCC	OS	Tertile	II,III,IV	0.562	0.943	.009	7	view →
LUAD	DFS	Tertile	All	0.931	0.538	.027	4	view →
PDAC	DFS	Quartile	III,IV	0.251	0.605	.045	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MPP1–CCRCC (DFS)

Open the CCRCC breakdown →