MPLKIP

Across TCGA pan-cancer cohorts, MPLKIP Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MPLKIP data layer compared with 20 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher MPLKIP Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MPLKIP expression acts as an unfavorable survival marker.

SKCM, THYM, and STAD are the cancer types where MPLKIP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.036	0.738	<.001	36	view →
THYM	OS	Median	All	0.068	0.977	<.001	24	view →
STAD	OS	Median	II,III,IV	0.183	0.677	.004	24	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MPLKIP–SKCM (DFS)

Open the SKCM breakdown →