MPLKIP

Across TCGA patient cohorts, MPLKIP mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPLKIP-associated genes across cancer lineages are RNU6-687P, RNA5SP94, and MIR5584. Each is linked with MPLKIP in more than 1 cancer types. Because this analysis shows association rather than direction, both MPLKIP-to-partner and partner-to-MPLKIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-687P grouped by MPLKIP-low versus MPLKIP-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPLKIP→partner) and Y-score (partner→MPLKIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-687P →	+0.571	+7.731	<.001	.009	3	1
BRCA	RNA5SP94 →	+0.291	+7.731	<.001	.009	3	1
BRCA	MIR5584 →	+0.458	+7.731	<.001	.009	3	1
BRCA	RNU6-543P →	+0.293	+8.055	<.001	.007	3	1
BRCA	RNA5SP87 →	+0.468	+8.055	<.001	.007	3	1
BRCA	RNU7-62P →	+0.450	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

RNU6-687P by MPLKIP expression — BRCA

Explore this box plot interactively →