MPLKIP

Across TCGA cell cohorts, MPLKIP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,200 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MPLKIP-associated GO terms across cancer lineages are Meiotic mismatch repair, Positive regulation of isotype switching to IgG isotypes, and Purine ribonucleotide biosynthetic process. Each is linked with MPLKIP in more than 10 cancer types. Because this analysis shows association rather than direction, both MPLKIP-to-partner and partner-to-MPLKIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic mismatch repair grouped by MPLKIP-low versus MPLKIP-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MPLKIP→partner) and Y-score (partner→MPLKIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Meiotic mismatch repair →	+0.119	+0.737	<.001	.002	3	11
BLOOD_Lymphoma	Positive regulation of isotype switching to IgG isotypes →	+0.146	+1.084	<.001	<.001	3	10
BONE	Purine ribonucleotide biosynthetic process →	+0.080	+0.627	.002	.003	3	8
BLOOD_Lymphoma	ER to Golgi ceramide transport →	+0.085	+0.681	<.001	<.001	2	9
BLOOD_Leukemia	Intermembrane lipid transfer →	+0.055	+0.374	<.001	.001	3	7
SOFT_TISSUE	Regulation of exocytosis →	-0.028	-0.327	.003	.008	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,200 associations by consensus.

Meiotic mismatch repair by MPLKIP expression — BLOOD_Lymphoma

Explore this box plot interactively →