MPL

Across TCGA patient cohorts, MPL protein abundance is significantly associated with the RNA expression of many other genes, with 945 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MPL-associated genes across cancer lineages are SEZ6L, HIF1A, and EEF1A2. Each is linked with MPL in more than 1 cancer types. Because this analysis shows association rather than direction, both MPL-to-partner and partner-to-MPL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MPL versus SEZ6L in GBM, with a Pearson correlation of -0.90.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPL→partner) and Y-score (partner→MPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEZ6L →	-4.177	-0.599	<.001	.001	3	1
GBM	HIF1A →	+1.180	+0.583	<.001	.002	3	1
GBM	EEF1A2 →	-2.514	-0.599	.005	.001	3	1
GBM	PCDH11X →	-2.039	-0.563	.007	.004	3	1
GBM	MMP15 →	-1.202	-0.599	.001	.001	3	1
GBM	SLC7A6OS →	-0.482	-0.599	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 945 associations by consensus.

MPL vs SEZ6L — GBM

Explore this scatter interactively →