MPL

Across TCGA patient cohorts, MPL mutation is significantly associated with the RNA expression of many other genes, with 3,366 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPL-associated genes across cancer lineages are CCNJP1, RNU1-141P, and OR5L1. Each is linked with MPL in more than 2 cancer types. Because this analysis shows association rather than direction, both MPL-to-partner and partner-to-MPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNJP1 grouped by MPL-low versus MPL-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPL→partner) and Y-score (partner→MPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	CCNJP1 →	+0.025	+4.669	<.001	.007	3	3
HNSC	RNU1-141P →	+0.282	+4.578	<.001	.008	3	3
BRCA	OR5L1 →	+0.029	+7.731	<.001	.009	3	2
UCEC	BAG3 →	+0.579	+2.459	<.001	<.001	3	2
UCEC	AQP7P4 →	+0.029	+2.568	.001	.005	3	2
UCEC	RRP12 →	+0.359	+2.102	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,366 associations by consensus.

CCNJP1 by MPL expression — CESC

Explore this box plot interactively →