MPL

Across TCGA patient cohorts, MPL mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPL-associated genes across cancer lineages are p27_pT198, VEGFR2, and 14-3-3_beta. Each is linked with MPL in more than 1 cancer types. Because this analysis shows association rather than direction, both MPL-to-partner and partner-to-MPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by MPL-low versus MPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPL→partner) and Y-score (partner→MPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.101	+3.321	.019	.010	3	2
UCEC	VEGFR2 →	+0.305	+1.920	.010	.009	3	2
UCEC	14-3-3_beta →	-0.102	-2.432	.011	.018	3	1
UCEC	EGFR_pY1068 →	-0.272	-2.700	.007	.006	3	1
UCEC	A-Raf_pS299 →	-0.182	-3.584	<.001	.002	3	1
UCEC	ERK2 →	+0.237	+3.459	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

p27_pT198 by MPL expression — UCEC

Explore this box plot interactively →