MPL

Across TCGA cell cohorts, MPL RNA expression is significantly associated with the RNA expression of many other genes, with 4,558 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MPL-associated genes across cancer lineages are MZF1, LEPROT, and NR0B2. Each is linked with MPL in more than 3 cancer types. Because this analysis shows association rather than direction, both MPL-to-partner and partner-to-MPL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MPL versus MZF1 in UPPER_AERODIGESTIVE_TRACT, with a Pearson correlation of 0.53.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPL→partner) and Y-score (partner→MPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MZF1 →	+1.485	+0.108	<.001	.002	3	3
BLOOD_Leukemia	LEPROT →	+0.940	+1.176	<.001	<.001	3	3
LUNG_SCLC	NR0B2 →	+2.097	+0.226	.003	.001	3	3
KIDNEY	FBXO21 →	+0.750	+0.121	.001	.003	2	4
BLOOD_Leukemia	SIK3 →	+0.748	+1.357	<.001	.001	2	4
KIDNEY	ZNF620 →	+1.077	+0.164	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,558 associations by consensus.

MPL vs MZF1 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →