MPL

Across TCGA cell cohorts, MPL mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MPL-associated genes across cancer lineages are P2RY10, R3HDML, and REG3G. Each is linked with MPL in more than 1 cancer types. Because this analysis shows association rather than direction, both MPL-to-partner and partner-to-MPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P2RY10 grouped by MPL-low versus MPL-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPL→partner) and Y-score (partner→MPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	P2RY10 →	+0.089	+4.263	<.001	.002	3	1
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	REG3G →	+0.026	+4.867	.004	.009	3	1
BLOOD_Leukemia	C14orf177 →	+0.076	+4.922	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

P2RY10 by MPL expression — SKIN

Explore this box plot interactively →