Across TCGA pan-cancer cohorts, MPIG6B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MPIG6B data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MPIG6B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MPIG6B expression acts as an unfavorable survival marker.

LSCC, GBM, and UCEC are the cancer types where MPIG6B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.361	1.000	.013	23	view →
GBM	OS	Median	All	0.396	0.627	.036	6	view →
UCEC	DFS	Median	All	0.650	1.000	.022	4	view →
LUAD	DFS	Quartile	All	0.789	1.000	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: MPIG6B tumor-vs-normal RNA expression · all MPIG6B data types