Across TCGA patient cohorts, MPIG6B mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPIG6B-associated genes across cancer lineages are S6_pS240_S244, STAT3_pY705, and c-Kit. Each is linked with MPIG6B in more than 1 cancer types. Because this analysis shows association rather than direction, both MPIG6B-to-partner and partner-to-MPIG6B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPIG6B→partner) and Y-score (partner→MPIG6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.744	+3.169	<.001	.019	3	1
UCEC	STAT3_pY705 →	-0.364	-2.990	.011	.036	3	1
UCEC	c-Kit →	-0.256	-3.169	.046	.020	3	1
UCEC	ERK2 →	+0.333	+3.169	.001	.020	2	1
UCEC	p27_pT198 →	+0.166	+3.169	.004	.020	1	2
UCEC	Caspase-7-cleavedD198 →	+0.953	+3.169	.003	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

MPIG6B survival (RNA) · tumor vs normal (RNA) · all MPIG6B data types